Enzymatica Q1: Continued growth in own markets, but a lack of partner orders

Research Update

2024-04-26

06:55

Redeye provides an update following Enzymatica’s Q1 report. The quarter’s sales did not meet our expectations, which resulted from low partner orders. We argue the company has an important time ahead and view a rise in partner sales as a trigger for the share. Moreover, we make changes to our sales estimates, rendering an updated fair value range.

GM

Gustaf Meyer

Contents

Investment thesis

Q1 2024 review

Events during the reporting period

Share price development

Financials

Q2 2024e preview

Valuation

Quality Rating

Financials

Rating definitions

The team

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Q1 2024 review

The sales for Q1 came in at SEK9.4m (SEK13.0m), 43% under our sales estimate of SEK16.6m. The declining sales compared to Q1 2023 are attributed to low partner orders. Enzymatica has had problems with partner sales since last year. The plan is to find a new partner in existing markets or in new markets. We argue this will be highly important in terms of future sales growth. However, sales in the company’s own markets grew during the quarter, for example, 21% in Sweden compared to last year’s Q1. As the sales mainly came from Enzymatica’s own markets, the gross margin was solid at 69% (61%) compared to our estimate of 61%. Moreover, operating expenses amounted to SEK-24.9m (SEK-22.3m) compared to our estimate of SEK-22.5m. Lastly, EBIT came in at SEK-18.4m compared to our estimate of SEK-12.4m, where the main difference is because of the lower sales.

MDR certification

Enzymatica announced that it has received an MDR certification for its mouth spray, ColdZyme, which treats and relieves cold and flu-like symptoms. MDR replaces the previous EU regulation MDD and demands stricter clinical evidence, safety design, and market surveillance requirements.
ColdZyme is now one of the first flu- and cold products to be certified under the new regulation. In our view, the certification did not come as a surprise; however, it is an important and essential milestone for Enzymatica. The new certification validates ColdZyme, which is positive from a commercial perspective, as ColdZyme’s benefits and efficacy can be more clearly communicated to customers. It is also positive in conversations with partners in current and future markets.

Updated fair value range

We decrease our sales estimates between 2024e-2026e. As a result, our fair value range based on our DCF model (2024e-2036e) is updated. We now have a base case of SEK5.5 (6.0), a bull case of 12.5(13.0), and an untouched bear case of SEK1.5. In our base case, we expect the company to become profitable in 2026e, reaching an EBIT margin of 17% where the sales growth is based on traction in major markets such as USA and China. Moreover, we apply a terminal growth rate of 2% and a terminal EBIT margin of 25%. The Enzymatica share is currently traded between our bear and base case. We argue that the main trigger throughout 2024 will be rising partner sales, where upcoming quarterly reports could decrease the valuation gap to our base case.

Key financials

SEKm202220232024e2025e2026e
Revenues48.950.965.9154.0278.9
Revenue Growth-14.5%4.0%29.5%134%81.1%
EBITDA-68.2-48.1-54.7-9.247.4
EBIT-68.2-48.1-54.7-9.247.4
EBIT Margin-139%-94.4%-83.0%-6.0%17.0%

Source: Redeye research (forecasts)

Investment thesis

Case

Global launch

Enzymatica’s product, ColdZyme, is a medical device that treats and alleviates the common cold and shortens its duration. The company is responsible for ColdZyme sales in the Swedish market and has, with distributors, launched the device in more than 30 markets worldwide. It aims to expand this to launches into another 30 markets over the next three years and its global rollout should expand its sales significantly in the coming years. As its distributors cover the launch expenses, we argue the product can generate significant sales for Enzymatica while not increasing the company’s costs significantly. We expect an EBIT margin of 25% at the end of our forecast period (2036e).

Evidence

Well-known distributors and solid track record

We highlight Enzymatica’s distribution agreements as these are with well-known players with expansive global networks, which we consider essential for the geographical expansion of ColdZyme. These partners are responsible for the majority of markets in which ColdZyme has been or will be launched. Statista values the Swedish cold and cough market at SEK1.3bn, and we assume ColdZyme has a current market share of around 3-5%. The establishment of this market in Sweden convinces us of the apparent demand for the product. Moreover, according to a market study, ColdZyme is Swedish pharmacists’ most recommended common cold product. We argue ColdZyme can establish itself in larger markets where the competition is similar to Sweden, while its distributors’ activity creates further conviction in these expectations.

Challenge

Regulatory changes

Regulatory requirements often change and can differ between markets. In 2017, STADA launched ColdZyme in Germany, where it was initially a success. However, the product was taken off the market due to local and national marketing requirements that demanded clinical data. We argue it is crucial for Enzymatica to continue performing studies on ColdZyme, as additional data can be useful to support future regulatory changes and new territories.

Challenge

Finding the right partners

As Enzymatica’s business model is reliant on the distribution partners, we highlight the importance of finding the right partners in markets where regulatory requirements are dynamic and ColdZyme has not yet been launched. Enzymatica does not have distribution agreements in much of Asia or in the US, which are large markets with considerable future potential. The choice of distribution partner is crucial for future success and so we regard this as a possible challenge.

Valuation

Great long-term potential

We believe Enzymatica’s current share price level does not reflect the potential in ColdZyme’s geographical expansion. As Enzymatica continues its global launch of ColdZyme, we believe quarterly reports and new market launches will represent potential triggers for the share that we expect can close the gap to our base case within the next c18 months.

Q1 2024 review

Income statement

The sales for Q1 came in at SEK9.4m (SEK13.0m), 43% under our sales estimate of SEK16.6m. The declining sales compared to Q1 2023 are attributed to low partner orders. Enzymatica has had problems with partner sales since last year. The plan is to find a new partner in existing markets or in new markets. We argue this will be highly important in terms of future sales growth. However, sales in the company’s own markets grew during the quarter, for example, 21% in Sweden compared to last year’s Q1. As the sales mainly came from Enzymatica’s own markets, the gross margin was solid at 69% (61%) compared to our estimate of 61%.

Moreover, operating expenses amounted to SEK-24.9m (SEK-22.3m) compared to our estimate of SEK-22.5m. The operating expenses were mainly selling expenses and administrative expenses. The selling expenses were a bit higher than anticipated (SEK2.7m); other than that, the individual line items aligned with our expectations. Lastly, EBIT came in at SEK-18.4m compared to our estimate of SEK-12.4m, where the main difference is because of the lower sales.

Cash position

The cash flow from operating activities was SEK-7.3m (SEK-12.1m), and by the end of the quarter, the cash and cash equivalents amounted to SEK26.9m (plus SEK0.1m in unutilized credit facilities). In February, Enzymatica carried out a fully secured rights issue of SEK27.4m (before issue-related costs of SEK1.9m) with a subscription period between February 28, 2024, and March 13, 2024. We had already included a rights issue in our model (SEK30m). Therefore, we were not surprised by the announcement, and the dilution effect was already included in our valuation of Enzymatica.

We argue there is a scenario where the current cash position will not be sufficient to cover the company’s business activities throughout 2024. Therefore, we highlight the importance of increasing partner sales during the rest of the year. However, we do not currently include a further capital injection into our model, as we would like to get a better picture of future partnerships.

Our overall thought of the report and CEO message

Overall, the report did not live up to our expectations, as we had expected some partner sales during Q1. The CEO message gave mixed feelings as the CEO is not satisfied with the disclosed sales; however, he is positive towards the future and believes Enzymatica will take important steps during the year. The MDR certification is an essential milestone for the company and will be important in talks with potential partners and new marketing activities.

Q1 2024e vs Q1 2024 actual (SEKm)
FY 2023Q1 23Q2 23Q3 23Q4 23Q1 24Q1 24edev. %dev. abs.
Net sales50.913.08.813.315.89.416.6-43%-7.1
Growth y/y4%213%-9%-28%-5%-28%27%-55%
Gross profit31.97.95.58.310.26.510.1-36%-3.6
Gross margin63%61%63%62%64%69%61%
Selling expenses-28.4-9.8-3.8-5.2-9.5-10.7-8.033%-2.7
Administrative expenses-39.4-9.1-9.7-9.7-10.9-10.2-10.7-4%0.5
R&D expenses-15.3-3.5-3.6-2.3-5.8-4.4-4.010%-0.4
Other op. Income/expenses3.20.20.40.22.30.50.378%0.2
OPEX-79.9-22.3-16.6-17.0-23.9-24.9-22.511%-2.4
EBIT-48.1-14.4-11.2-8.7-13.8-18.4-12.449%-6.0
EBIT margin-94%-110%-127%-66%-87%-195%-75%-121%
Source: Redeye research (forecasts)

Events during the reporting period

Rights issue

In February, Enzymatica announced it had decided to carry out a rights issue of SEK27.4m, with preferential rights for existing shareholders. The rights issue aimed to secure the working capital needed for the operations and expansion in existing and new markets. Under the rights issue terms, one existing share in Enzymatica carried one subscription right, while 18 subscription rights entitled the holder to subscribe to one new share at the price of SEK3.0 per share. We also learned that the rights issue has been fully secured by the company’s three largest shareholders, the chairman, two members of the board, and Enzymatica’s CEO.

The subscription period ran between February 28, 2024, and March 13, 2024. The share capital increased by SEK365,015 and the number of shares by 9,125,380, from 164,256,840 to 173,382,220, representing a dilution of approximately 5.6%.

In March, we learned that the rights issue was subscribed by 72.7% with subscription rights and 7.9% without subscription rights. However, as mentioned, the remaining part of the rights issue was subscribed for through guarantee commitments by the company’s three largest owners through fully or partly owned companies, as well as the chairman of the board and the CEO.

MDR certification

Enzymatica announced that it has received an MDR certification for its mouth spray, ColdZyme, which treats and relieves cold and flu-like symptoms. MDR replaces the previous EU regulation MDD and demands stricter clinical evidence, safety design, and market surveillance requirements.

ColdZyme is now one of the first flu- and cold products to be certified under the new regulation. In our view, the certification did not come as a surprise; however, it is an important and essential milestone for Enzymatica. The new certification validates ColdZyme, which is positive from a commercial perspective, as ColdZyme’s benefits and efficacy can be more clearly communicated to customers. It is also positive in conversations with partners in current and future markets.

Share price development

The Enzymatica share is down c15% during 2024 and up c35% during the last 12 months. The share has been relatively volatile during the last year, with ups and downs, fluctuating between SEK2-4. We believe that the sales during 2023 did not live up to the market’s expectations, and as the partnership with STADA has had a negative development, the uncertainties of future European sales have increased. However, on the other side, sales in Sweden grew steadily during 2023 and Q1 2024. Moreover, the market reacted positively to the MDR certification and clinical study results that were published during the autumn of 2023, study results that we believe will be important for marketing and partnerships for the company.

Moreover, we argue that 2024 is a year where Enzymatica needs to prove sales growth. The past years have not lived up to the market’s expectations, and we believe rising sales could be the major trigger for the share during the year.

Share price development since 2023

Source: Millistream, Redeye research

Financials

As the sales during the quarter did not live up to our expectations and there are still issues with partner sales, we have chosen to decrease our sales estimates for 2024e-2026e. Firstly, Q1 2024 sales came in SEK7.1m lower than anticipated, and we decrease our estimates between Q2-Q4 by SEK9.8m, now expecting FY 2024e sales of SEK65.9m. We still expect partner sales to rise during the year's second half, which will be crucial for the current cash position to be sufficient throughout the year. However, note that a potential new partnership could lead to an upfront payment. In that scenario, the company’s financial situation would be strengthened, decreasing the risk of capital raising. Furthermore, we decrease our 2025e-2026e sales estimates by around 20% due to uncertain partner sales.

Estimate changes 2024e-2026e

SEKm2024eOldChange2025eOldChange2026eOldChange
Revenues65.982.8(20.4%)154.0192.0(19.8%)278.9345.3(19.2%)
Operating Expenses91.489.02.7%95.595.50.0%105.6105.60.0%
EBIT-54.7-40.6(34.9%)-9.210.5(187.8%)47.481.9(42.1%)

Source: Redeye research (forecasts)

Q2 2024e preview

Historically, the second quarter has been Enzymatica’s weakest quarter in terms of sales. However, this is no surprise as the company’s sales of ColdZyme are highly affected by the flu season. We do not believe this year’s Q2 will differ and estimate sales of SEK8.6m. Moreover, we expect OPEX to be fairly aligned with Q1 (OPEX estimate in Q2 of SEK-17.3m) except for selling expenses, which are related to sales activities. Furthermore, we anticipate an EBIT for Q2 2024e of SEK-11.7m.

Income statements 2023-2026e (SEKm)
FY 2023Q1 24Q2 24eQ3 24eQ4 24eFY 2024eFY 2025eFY 2026e
Net sales50.99.48.621.835.665.9154.0278.9
Growth y/y4%-28%-2%64%125%30%134%81%
Gross profit31.96.55.612.921.136.786.3153.0
Gross margin63%69%65%59%59%56%56%55%
Selling expenses-28.4-10.7-4.6-8.3-9.9-33.6-32.6-34.5
Administrative expenses-39.4-10.2-10.7-10.8-10.9-42.7-43.4-46.9
R&D expenses-15.3-4.4-2.3-3.7-6.1-16.5-21.7-27.6
Other op.Income/expenses3.20.50.30.30.31.42.23.5
OPEX-79.9-24.9-17.3-22.6-26.6-91.4-95.5-105.6
EBIT-48.1-18.4-11.7-9.6-5.5-54.7-9.247.4
EBIT margin-94%-195%-137%-44%-15%-83%-6%17%
Source: Redeye research (forecasts)

Valuation

As mentioned, we decrease our sales estimates between 2024e-2026e. As a result, our fair value range based on our DCF model (2024e-2036e) is updated. We now have a base case of SEK5.5 (6.0), a bull case of 12.5(13.0), and an untouched bear case of SEK1.5. In our base case, we expect the company to become profitable in 2026e, reaching an EBIT margin of 17% where the sales growth is based on traction in major markets such as USA and China. Moreover, we apply a terminal growth rate of 2% and a terminal EBIT margin of 25%. The Enzymatica share is currently traded between our bear and base case. We argue that the main trigger throughout 2024 will be rising partner sales, where upcoming quarterly reports could decrease the valuation gap to our base case.

Peer valuation

In addition to our DCF valuation, we offer a peer group analysis that compares Enzymatica with other medtech companies in the Nordic region with similar enterprise values. We consider EV/Sales the best measurement, as Enzymatica is not currently profitable.

CompanyEV (SEKm)20232024e2025e
Acarix7712.8x0.9x0.3x
Bactiguard250011.2x11.6x8.3x
Dignitana1311.5x1.2x0.6x
Midsona16410.4x0.4x0.4x
Moberg pharma492491.8x98.4x5.0x
Sedana Medical10696.9x5.8x2.8x
Stille7772.6x1.5x1.1x
Xvivo Perfusion1112718.6x13.7x7.7x
Median9239.1x3.7x2.0x
Enzymatica56311.1x8.5x3.7x
Source: Factset, Redeye research

When comparing Enzymatica to other medtech companies, we can observe that the Enzymatica share currently trades at 11.1x times its 2023 sales and 8.5x its 2024e sales. As can be observed, Enzymatica is currently valued a bit higher than its selected peers, especially the EV/Sales multiple for 2024e. We highlight two things from the peer valuation. Firstly, one should notice the difference between Enzymatica and the selected peers. Secondly, life sciences companies’ valuations have generally decreased significantly during the last year; however, Enzymatica’s valuation has been relatively stable. This indicates that the market currently has high expectations of the company.

Quality Rating

People: 4

The management team is solid and brings extensive experience from commercial and growth companies. In addition, there is strong sector expertise. The board brings extensive experience in life science and growth companies. It is also positive that the largest shareholder, Mats K Andersson, is one of the board members.

Business: 3

The business model is appealing, with a solid strategy to become profitable in the future. Enzymatica has already established ColdZyme in Sweden, creating conviction in a successful global expansion. We are positive about the company’s well-known distribution partners as they will be crucial for Enzymatica’s future growth.

Financials: 1

Enzymatica has a few years ahead of it before it turns profitable. Through its global expansion of ColdZyme, however, we believe the company will become profitable in 2025.

Financials

Income statement
SEKm20232024e2025e2026e
Revenues50.965.9154.0278.9
Cost of Revenue19.029.367.8125.9
Operating Expenses79.991.495.5105.6
EBITDA-48.1-54.7-9.247.4
Depreciation5.03.95.46.9
Amortizations1.43.95.46.9
EBIT-48.1-54.7-9.247.4
Shares in Associates0.000.000.000.00
Interest Expenses2.31.60.000.00
Net Financial Items-1.7-1.50.000.00
EBT-49.7-56.2-9.247.4
Income Tax Expenses0.01-0.310.000.00
Net Income-49.7-55.3-9.247.4
Balance sheet
Assets
Non-current assets
SEKm20232024e2025e2026e
Property, Plant and Equipment (Net)16.514.111.710.4
Goodwill0.000.000.000.00
Intangible Assets68.365.863.467.7
Right-of-Use Assets0.000.000.000.00
Other Non-Current Assets9.99.99.99.9
Total Non-Current Assets94.789.785.088.0
Current assets
SEKm20232024e2025e2026e
Inventories11.56.615.427.9
Accounts Receivable11.313.223.127.9
Other Current Assets0.000.000.000.00
Cash Equivalents8.4-8.9-13.623.2
Total Current Assets31.210.924.979.0
Total Assets125.9100.6109.9166.9
Equity and Liabilities
Equity
SEKm20232024e2025e2026e
Non Controlling Interest0.000.000.000.00
Shareholder's Equity76.646.937.685.0
Non-current liabilities
SEKm20232024e2025e2026e
Long Term Debt24.924.924.924.9
Long Term Lease Liabilities0.000.000.000.00
Other Long Term Liabilities0.000.000.000.00
Total Non-Current Liabilities24.924.924.924.9
Current liabilities
SEKm20232024e2025e2026e
Short Term Debt1.21.21.21.2
Short Term Lease Liabilities0.000.000.000.00
Accounts Payable7.47.915.427.9
Other Current Liabilities15.819.830.827.9
Total Current Liabilities24.428.947.457.0
Total Liabilities and Equity125.9100.6109.9166.9
Cash flow
SEKm20232024e2025e2026e
Operating Cash Flow-40.3-40.01.453.5
Investing Cash Flow-0.73-2.8-6.2-16.7
Financing Cash Flow-1.425.50.000.00

Source: Redeye research (forecasts)

Rating definitions

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Contents

Investment thesis

Q1 2024 review

Events during the reporting period

Share price development

Financials

Q2 2024e preview

Valuation

Quality Rating

Financials

Rating definitions

The team

Download article